Heal Your Gut

Heal Your Gut, Save Your Brain by Partha Nandi

Five Pillars for Gut Health and Cognitive Optimization

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✍️ Partha Nandi ✍️ Science

Table of Contents

Introduction

Summary of the book Heal Your Gut, Save Your Brain by Partha Nandi. Before moving forward, let’s briefly explore the core idea of the book. Imagine holding a secret key that unlocks a pathway to lifelong mental vitality—this book provides that key. Within these pages, you’ll travel inside your body’s hidden ecosystems, discovering how your gut and brain share messages that shape how you think, feel, and remember. Instead of waiting for serious problems to arise, you’ll learn proactive steps to strengthen your internal environment. Through stories, research, and practical advice, you’ll understand why nourishing your microbiome isn’t just about comfort after meals, but also about safeguarding your memory, mood, and creativity. Armed with this knowledge, you can choose foods, adopt habits, and live in ways that help your mind stay vibrant. This journey offers more than information; it offers hope that simple changes—like adding more leafy greens to your plate or sleeping in a healthier position—can add up to a lifetime of clearer thinking, better resilience, and a brighter, more fulfilling future.

Chapter 1: Uncovering the Hidden Pathways: Understanding the Profound Link Between Your Gut and Brain for a Healthier, Sharper Mind .

Imagine the human body as a bustling city of countless interconnected roads, where signals constantly travel back and forth, ensuring everything runs smoothly. Within this metropolis lies a surprisingly active communication line between two vital organs: your gut and your brain. Although this may seem strange at first—after all, what do your intestines have to do with your thoughts?—modern science has uncovered an astonishing truth. Far beyond merely digesting meals, your gut acts like an information hub, exchanging chemical and electrical messages with your brain around the clock. Early researchers thought the brain was always in charge, sending orders down through nerves to keep digestion moving. However, new discoveries reveal a two-way street, where the gut’s own community of microorganisms can influence how you think, feel, and remember. Understanding this connection is not just about learning a curious fact; it’s about unlocking a powerful tool to improve lifelong mental clarity.

A personal story helps illuminate just how deeply this connection matters. Decades ago, a talented scientist named Professor Uma Nandi suffered a severe stroke, losing the ability to move one entire side of his body. His son, Dr. Partha Nandi, witnessed this tragedy and dedicated himself to unraveling the hidden factors that influence brain health. He found that the gut’s bacterial ecosystem was not a simple background character, but a key player in shaping neurological outcomes. This realization challenged long-held assumptions and sparked a new field of medical study focused on how gut health influences everything from recovering after a stroke to maintaining sharp thinking in old age. By investigating this relationship, Dr. Nandi aimed to help people understand that protecting your mind is not just about puzzles or reading books—it might start with what’s happening deep in your digestive system, often long before obvious symptoms appear.

Scientific findings now reveal that the gut is home to trillions of microbial inhabitants—tiny bacteria, fungi, and other organisms that form a dynamic neighborhood inside the intestines. These microscopic residents help digest food, produce vitamins, and create substances that directly influence your nervous system. Think of them as a hidden workforce whose daily tasks impact your mental well-being. When these friendly microbes thrive, they send positive signals, reduce inflammation, and help maintain a stable mood. However, when their delicate balance is disrupted, the gut can become a source of trouble, fueling problems that extend far beyond a tummy ache. By exploring the microscopic universe within, we learn that what happens in your abdomen doesn’t stay there; it ripples throughout your body, affecting the brain’s delicate networks. Recognizing this intricate relationship sets the stage for strategies to keep both gut and mind healthy for many years to come.

The implications are enormous. Research points to connections between gut imbalances and cognitive decline, including conditions like dementia, Parkinson’s, and Alzheimer’s disease. Scientists once believed these neurological disorders sprang solely from genetic vulnerabilities or environmental toxins. Now, they are discovering that gut health can play a decisive role, either accelerating damage or helping slow it down. By understanding how the gut and brain communicate, we unlock a powerful window of opportunity to intervene. Adjusting dietary habits, using targeted supplements, and managing lifestyle factors can influence the microbiome’s composition, reduce harmful inflammation, and support healthier brain function. This awareness also empowers everyday people—teens, parents, seniors—to make more informed choices. You don’t have to wait until illness strikes; you can start nurturing your microbiome early, planting seeds that may help safeguard your mental abilities. This chapter lays the foundation for grasping this life-changing concept, motivating you to read on.

Chapter 2: Navigating the Inner Ecosystem: How Microscopic Gut Inhabitants Steer Your Mood, Memory, and Mental Focus .

Your gut’s inner world resembles a sprawling ecosystem with countless residents playing unique roles. Within its twisting tunnels, billions of bacteria, viruses, and fungi coexist, forming intricate webs of cooperation and competition. Some microbes specialize in breaking down fibers, generating essential nutrients that feed your intestinal lining. Others help produce signaling molecules that travel through your bloodstream and influence your brain’s chemistry. A healthy gut hosts an abundance of beneficial microbes, each type contributing to a balanced environment. Just as a diverse rainforest teems with life and stability, a varied gut microbiome can foster resilience, protecting you against both physical and mental threats. But just as a rainforest can wither when invaded by harmful species, your gut can suffer if disease-causing microbes multiply. This delicate balance determines whether the messages sent to your brain are soothing and supportive—or inflammatory and disruptive, altering everything from mood to memory.

When your gut is in harmony, it communicates smoothly with your central nervous system. Beneficial bacteria produce short-chain fatty acids, like butyrate, that strengthen the intestinal barrier, preventing harmful compounds from leaking into your bloodstream. These helpful microbes also support the production and regulation of neurotransmitters—chemical messengers like serotonin and dopamine that shape how you feel and think. As a result, a healthy gut can contribute to steadier moods, sharper focus, and a more stable emotional state. You might notice feeling calmer after meals rich in fiber or experiencing improved mental clarity after incorporating probiotic foods into your diet. By contrast, when the microbiome is unbalanced, the body’s protective barriers can weaken, allowing inflammation to spread. Over time, this may cloud your thinking, reduce concentration, and even encourage the buildup of damage in brain cells, setting the stage for serious cognitive decline.

It’s not just older adults who should care about this. Even teenagers and young adults can be affected by microbiome shifts that influence stress management and emotional well-being. Have you ever felt nervous butterflies before a big test or a school presentation? That sensation might partly arise from communication between gut and brain. Although everyone experiences stress, long-term imbalances can create ongoing anxiety, foggy thinking, and mood swings. Thankfully, choices you make—such as incorporating more vegetables into your meals or reducing excessive sugar—can help keep your gut inhabitants healthy. Over time, these positive steps may ease mental tension, allowing you to handle challenges more confidently. By understanding that your digestive system is intimately connected to your mind, you gain a new perspective: feeding your gut the right foods and nurturing a healthy microbiome can support a calmer and more focused version of yourself, at any age.

As researchers delve deeper, they uncover how specific microbial species interact with your nervous system, influencing learning, memory formation, and even sleep quality. Some microbes release metabolites that help maintain the brain’s cellular repair processes, potentially slowing age-related decline. Others contribute to the production of key vitamins, like certain B vitamins, crucial for brain energy and function. This evolving knowledge reveals the microbiome as a versatile toolkit for mental health. Instead of viewing your gut merely as a place to digest meals, imagine it as your personal command center, sending helpful signals and supporting your brain’s performance. Understanding that an unseen community of microorganisms plays a pivotal role in cognition and emotional balance empowers you to become more involved in your own health. By thoughtfully adjusting diet, lifestyle, and supplementation, you take control, steering your inner ecosystem toward a future of greater mental resilience and well-being.

Chapter 3: Fortifying the Inner Fortresses: How a Strong Gut Barrier Shields Your Brain and Shapes Your Future Health .

Picture your gut barrier as a high-tech security checkpoint, similar to a fortified border that carefully decides who enters and who stays out. This barrier consists of a thin but remarkably selective layer of cells lining your intestine. It must let in essential nutrients, vitamins, and water from the food you eat, while blocking harmful bacteria, toxins, and undigested particles. If everything runs smoothly, this system helps maintain order, ensuring only the good stuff passes through to your bloodstream. Yet if something goes wrong—like continuous exposure to poor-quality foods or stress that disturbs the microbial balance—the barrier can weaken. Tiny gaps might open, allowing unwanted substances to slip through and trigger inflammation. Over time, these harmful elements can travel beyond the gut, potentially affecting your brain. That’s why guarding the gut barrier is so important: it’s a critical line of defense against threats that may harm your mind.

This protective function is supported by the Enteric Nervous System (ENS), a branch of the nervous system housed within the gut. Often called the second brain, the ENS contains millions of nerve cells working independently and in harmony with your central nervous system. Like dedicated customs officers, these nerves scrutinize what passes through, helping ensure that dangerous intruders don’t enter circulation. When the gut barrier and the ENS collaborate well, they help maintain a stable internal environment. The result is improved nutrient absorption, steady energy levels, and a balanced mood. If something compromises this partnership—perhaps a microbial imbalance, chronic stress, or inflammatory foods—the security weakens. As these intruders slip into your bloodstream, they may trigger immune responses that rattle the body’s equilibrium and may even cross into your brain, potentially contributing to memory issues, reduced concentration, or other cognitive difficulties.

One of the key players in maintaining the gut barrier’s integrity is the community of beneficial bacteria. These friendly microbes produce compounds like short-chain fatty acids that nourish the cells lining your intestines, helping them stay strong and tight. It’s like feeding the guards at the border with a steady diet of healthy meals so they remain vigilant and effective. When you supply your gut with the right foods—fibers from vegetables, fruits, whole grains, and legumes—you encourage the growth of these helpful bacteria. In contrast, diets loaded with processed sugars, unhealthy fats, and chemical additives can promote harmful microbes, creating a toxic environment that chips away at the barrier’s defenses. Over time, this may lead to leaky gut, an unpleasant scenario where the gates no longer discriminate well, allowing disease-promoting substances to infiltrate and place your brain’s health at significant risk.

Paying attention to subtle signs can help you detect a compromised gut barrier before it becomes a big problem. Maybe you’ve started feeling unusually tired, even when you sleep enough. Perhaps you struggle to stay focused or find that your memory feels fuzzy. You might notice stomach discomfort, bloating, or unexplained skin issues. Although these signs can have multiple causes, they often hint at an imbalance in the gut’s ecosystem. By learning to listen to these signals, you can take steps to fortify your internal fortresses. Choosing more whole foods, learning stress management techniques, and considering specific supplements can patch up the walls, helping restore proper function. Think of it as investing in security upgrades that protect not only your digestion, but also your long-term brain health. By actively supporting the gut barrier, you provide a strong foundation for your mind to flourish in the years ahead.

Chapter 4: Transforming Your Plate into a Natural Pharmacy: Using Everyday Foods to Revitalize Your Gut and Sharpen Your Brain .

The grocery store you visit every week might seem ordinary, but it’s actually packed with powerful remedies. Instead of pills and potions, these cures come in the form of fresh produce, whole grains, lean proteins, and nourishing fats. By carefully choosing and preparing foods at home, you can create meals that help restore balance to your gut, which in turn supports clearer thinking and stronger mental resilience. Cooking at home allows you to control what goes into your body, reducing the hidden sugars, unhealthy fats, and chemical additives often found in packaged products. This doesn’t require expensive chef skills—just a willingness to experiment with simple ingredients. By taking charge of what you eat, you begin to see your kitchen not just as a place to fill your stomach, but as a personal workshop for crafting meals that improve both digestive comfort and mental well-being.

Central to this approach is a diet rich in plant-based foods. Vegetables of all colors—leafy greens, bright carrots, and deep-purple eggplants—deliver essential fiber and micronutrients that feed beneficial gut bacteria. Whole grains like oatmeal, brown rice, and quinoa offer sustained energy and help keep your inner environment stable. Legumes, such as lentils and chickpeas, provide protein along with prebiotic fibers that nurture healthy microbes. Add garlic, onions, and leeks to your dishes, and you’ll serve up compounds that encourage beneficial bacteria to flourish. If you’re feeling adventurous, include fermented foods—like kimchi, sauerkraut, or kefir—to introduce friendly probiotic strains. Over time, these dietary choices help restore order in your gut, reducing inflammation and allowing the brain to function more efficiently. Gradually, you’ll notice changes: feeling more alert after breakfast, staying focused in the afternoon, and enjoying a calmer evening routine.

Beyond the foods themselves, how you eat matters. Slow down when you dine, savoring each bite rather than rushing. This mindful approach allows your digestive system to work at its best, breaking down nutrients effectively and signaling your brain that you’re satisfied. Instead of multitasking during meals, focus on the flavors, textures, and aromas. This creates a positive feedback loop—enjoying meals leads to better digestion, which supports a healthier microbiome, ultimately contributing to improved mental clarity. Eating with friends and family can further enrich this experience. Conversations at the dinner table, the laughter you share, and the bond you strengthen can all reduce stress, promoting a more balanced internal environment. In this way, the act of eating becomes more than fueling the body; it’s a way to nurture your inner world and, by extension, the quality of your thoughts and emotions.

Over time, these dietary habits form a natural rhythm that aligns with your body’s needs. By consciously choosing fresh produce over processed snacks, you’re investing in the health of your gut and brain. The changes may be gradual but noticeable—a bit more energy here, a sharper memory there, and a subtle lift in your mood. Eventually, these small shifts accumulate, leading to a significantly improved outlook on health. What once felt like a chore—cooking a simple meal—becomes an empowering activity, reminding you that you have the ability to influence your well-being. As you master these choices, you begin to understand that food as medicine isn’t just a trendy phrase; it’s a practical, affordable, and enjoyable strategy for better health. By transforming your plate into a natural pharmacy, you lay a sturdy foundation for protecting your mind and giving it the best chance to thrive.

Chapter 5: Culinary Allies Against Cognitive Decline: Building a Defense Line to Preserve Your Memory and Mental Vitality .

As you journey through life, you hope to maintain a keen mind—one that remembers birthdays, solves problems, and finds joy in learning new things. Yet cognitive decline can sneak up quietly, affecting your memory and thinking skills over time. Fortunately, the foods you eat can act like loyal allies, helping to preserve brain function. Certain dietary patterns, notably those rich in colorful vegetables, whole fruits, legumes, and moderate amounts of fish, have been linked to improved memory and problem-solving abilities. By choosing these nourishing foods, you’re giving your gut bacteria the nutrients they need to produce brain-supporting compounds and reduce harmful inflammation. You’re essentially constructing a protective barrier that may help slow down the natural wear and tear that occurs within your nervous system. Over the long run, this can mean better retention of memories, greater mental sharpness, and a more satisfying quality of life.

One effective strategy for building cognitive resilience is focusing on dietary patterns like the Mediterranean-style approach. This means enjoying plentiful veggies—think crisp bell peppers, leafy spinach, and sweet cherry tomatoes—drizzled with a bit of extra-virgin olive oil. Add in whole grains, such as barley or bulgur, and lean proteins like fish or legumes. This mix isn’t about strict rules; it’s about embracing balance and variety. Such a diet encourages a flourishing gut microbiome, one that generates key nutrients and signaling molecules that help preserve the brain’s wiring. As you reinforce this pattern, harmful processes like chronic inflammation may gradually recede, allowing your neurons to perform better. Studies have shown that individuals following these eating principles often enjoy steadier cognitive function, handling complex tasks more easily and retaining information more effectively. Over time, this can reduce the risk of developing serious memory-related conditions.

While the right diet builds a foundation, other lifestyle factors strengthen it further. For example, a regular exercise routine not only supports cardiovascular health but also improves gut function by increasing microbial diversity. Adequate sleep gives your body time to repair and regenerate cells, including those in your brain, while maintaining a balanced microbiome. Stress-management techniques—such as yoga, meditation, or simply taking breaks throughout the day—help stabilize hormone levels that affect digestion and mood. Consider these habits as reinforcements of your gut-brain alliance. When you combine healthy eating, physical activity, good sleep, and stress reduction, you provide your body a holistic platform from which it can defend against mental decline. These elements work together, each supporting and amplifying the other’s benefits, resulting in a more harmonious internal environment that helps protect long-term memory and cognition.

Investing in your mental vitality now can pay dividends later. Each nutrient-rich meal you prepare, each step you take during a brisk walk, each moment you spend unwinding instead of stressing—all contribute to your overall cognitive health. Think of it as adding coins to a piggy bank dedicated to preserving mental strength. As the months and years pass, you accumulate a wealth of protective measures that can slow or lessen age-related challenges. While there are no absolute guarantees, research strongly suggests that people who actively nourish their gut, maintain varied diets, and live balanced lifestyles are better equipped to hold onto their mental abilities. The path to healthier cognition isn’t about making drastic changes overnight; rather, it’s about steady improvements. Over time, this consistent effort can transform your future, helping you maintain a capable, adaptive, and creative mind throughout your life’s many stages.

Chapter 6: Turning the Tide on Neurodegenerative Threats: Gut-Centered Approaches to Prevent and Slow Alzheimer’s Disease .

The idea that Alzheimer’s disease might be influenced by what’s happening in your gut is both surprising and exciting. For decades, scientists focused primarily on the brain’s internal chemistry and genetic factors, searching for answers to why memory fades and thinking slows. Recently, however, research has revealed that certain patterns in the gut microbiome distinguish those at higher risk of Alzheimer’s. Harmful bacteria and inflammatory compounds can slip past weakened barriers, entering the bloodstream and potentially reaching the brain. There, they may accelerate the formation of toxic protein clumps that damage neurons. By understanding this gut-brain connection, new doors open. Instead of waiting until symptoms appear, you can act earlier—adjusting your diet to restore microbial balance, choosing foods that fight inflammation, and avoiding factors that allow damaging molecules to spread. This approach gives hope that people can influence their risk long before warning signs arise.

A dietary pattern rich in vegetables, fruits, whole grains, legumes, and healthy fats, especially those found in olives and certain fish, can support a healthier microbiome. These foods promote the growth of bacteria that produce beneficial substances, reinforcing the gut barrier and reducing systemic inflammation. For Alzheimer’s patients or those at risk, adopting such habits might help slow disease progression. Supplements can also play a role. Certain probiotic strains, carefully chosen, may enhance the gut’s defense mechanisms. Compounds like butyrate, naturally created by healthy gut bacteria, help maintain brain health by counteracting damaging processes. Additionally, ensuring adequate intake of nutrients like vitamin D supports both gut integrity and cognitive resilience. While these measures aren’t guaranteed cures, they represent concrete steps that may delay or lessen certain symptoms, giving individuals valuable time and improving their overall quality of life.

Another powerful tactic involves rethinking meal timing. Intermittent fasting—choosing specific periods during the day when you don’t eat—may activate the body’s natural cleanup crews. During fasting, cells enter a mode called autophagy, clearing away damaged components and waste products. This process can potentially help remove harmful protein buildups in the brain. At the same time, intermittent fasting encourages a healthier gut environment by promoting microbial diversity and reducing chronic inflammation. Although fasting requires careful planning to ensure you get proper nutrients, many find it surprisingly manageable once they establish a routine. Over time, these dietary rhythms can produce meaningful benefits, helping the body respond more effectively to early signs of neurodegeneration and possibly slowing its progress. The combination of thoughtful food choices, supplements, and strategically timed meals creates a comprehensive defense plan that begins in the gut and extends into the deepest reaches of the mind.

Embracing these strategies can positively ripple through a person’s life. Families dealing with Alzheimer’s find that shifting toward anti-inflammatory, gut-supporting diets not only helps the patient but also improves the general health of everyone at the table. Such communal changes create an environment where cooking together, sharing recipes, and supporting one another’s choices become part of everyday life. Over time, these bonds grow stronger, as does collective resilience. By recognizing that the journey toward preventing or managing Alzheimer’s involves more than just medication, individuals gain a sense of empowerment. They understand that the foods they eat, the timing of their meals, and the state of their gut microbiome can all influence how quickly or slowly the disease advances. This knowledge can inspire hope and motivate action, transforming what once felt like a helpless situation into a path lined with practical steps toward better health.

Chapter 7: Early Warnings in the Digestive World: Using Gut Clues to Halt Parkinson’s Progression Before It Strikes Hard .

Parkinson’s disease often brings to mind trembling hands, stiff muscles, and difficulty moving. But researchers are discovering that the earliest signs of this condition may appear in the gut, long before a single handshake turns shaky. By examining the microbiome of individuals who later develop Parkinson’s, scientists have identified distinctive patterns—some bacterial populations shrink, while others grow out of control. These imbalances can contribute to the formation of harmful protein aggregates that eventually spread to the brain, damaging the cells that produce dopamine, a critical chemical for smooth movement. Understanding these early gut-based signals offers a valuable opportunity. Rather than waiting for visible symptoms to emerge, you could potentially adjust your diet and lifestyle years earlier to shape a healthier environment inside the intestines. By doing so, you might reduce the chances of these dangerous proteins taking root and hastening the disease’s progression.

Just as with Alzheimer’s, dietary strategies can help you mount a defense against Parkinson’s. Green leafy vegetables, high-fiber whole grains, and nutrient-dense fruits support beneficial microbes and discourage overgrowth of harmful bacteria. Incorporating antioxidant-rich foods, like blueberries or dark leafy greens, helps combat inflammation that contributes to neuronal damage. Certain healthy fats—from sources like walnuts, flaxseeds, and wild-caught fish—may promote better brain cell function. Meanwhile, reducing red meat and heavily processed foods lightens the inflammatory load. Even something as simple as enjoying a cup of tea, with its gentle compounds that calm inflammation, can make a difference over time. By gradually shifting your meals to include these protective elements, you create a more stable internal environment. This approach might not prevent Parkinson’s entirely, but it could slow its approach, giving you more time with sharper focus, steadier hands, and a clearer mind.

Beyond food, other lifestyle adjustments support this gut-brain partnership. Sleep, for instance, plays a crucial role. Positioning yourself to sleep on your side can help the brain’s waste-clearing system operate more efficiently. This natural rinse cycle can remove unwanted proteins and toxins, potentially delaying their harmful effects. Engaging in regular exercise also stimulates circulation, oxygen delivery, and microbial balance, which can bolster both mood and movement. Additionally, learning to manage stress—through journaling, breathing exercises, or leisurely walks—helps keep hormone levels stable. This stability translates into a healthier gut environment, one less prone to inflammation and dysfunction. By investing in these habits, you build a scaffold of protective factors. Together, they may hold off the onset of severe symptoms, allowing you to enjoy daily activities longer and maintain a higher level of independence and comfort throughout your life.

This early focus on gut health represents a fundamental shift in how we think about preventing neurological disorders. Instead of viewing Parkinson’s solely as a brain disease that appears late in life, we can now recognize it as a condition that may begin stealthily, influenced by patterns hidden in the digestive system. This realization isn’t cause for fear; rather, it’s a source of motivation. You have a window of time—perhaps years or even decades—during which thoughtful dietary and lifestyle decisions could alter the disease’s path. By seeing the gut as a warning signal and taking action, you become an active participant in your own health story. This proactive stance doesn’t guarantee a future without challenges, but it does create hope. It shows that by paying attention to the hints your body gives you, you can navigate toward a healthier tomorrow with more confidence and control.

All about the Book

Discover profound healing insights in ‘Heal Your Gut, Save Your Brain’ by Partha Nandi. This transformative book empowers you to improve gut health, enhance brain function, and unlock your full potential for a healthier life.

Dr. Partha Nandi is a renowned physician and health advocate dedicated to promoting holistic health and wellness. His expertise bridges traditional medicine with innovative healing strategies.

Nutritionists, Health Coaches, Medical Doctors, Psychologists, Wellness Advocates

Cooking healthy meals, Practicing yoga, Gardening, Meditation, Exploring nutrition science

Gut microbiome health, Neurodegenerative diseases, Mental wellness, Chronic inflammation

When you heal your gut, you heal your mind, and unleash limitless potential for your life.

Dr. Mark Hyman, Deepak Chopra, Kristi Funk

Best Health Book of the Year 2022, National Indie Excellence Award, Readers’ Favorite Book Award

1. How can gut health influence brain function? #2. What are the symptoms of an unhealthy gut? #3. Can diet really affect mental well-being profoundly? #4. What role do probiotics play in gut health? #5. How can I identify food intolerances effectively? #6. What strategies help in reducing gut inflammation? #7. Are there specific foods that nourish the gut? #8. How does stress impact gut and brain connections? #9. Can mindfulness practices improve digestive health? #10. What is the gut-brain axis, and why it matters? #11. How can lifestyle changes enhance gut health? #12. Are there simple recipes to improve gut health? #13. What supplements support gut and brain wellness? #14. How does hydration relate to gut function? #15. Can fermented foods benefit my gut microbiome? #16. What habits are detrimental to gut health? #17. How can I track my gut health progress? #18. Can sleep patterns impact my gut’s well-being? #19. What is the best way to detoxify my gut? #20. How do emotions affect the digestive system?

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